Effects of Vernonia amygdalina methanol leaf extract and fractions on Ascaridia galli in experimentally infected birds with regard to its pathological effect

Abstract Background Helminthiasis, usually a chronic problem in poultry, is the major cause of economic losses poultry industry. This study was undertaken with aim evaluating vitro and vivo anthelmintic effects Vernonia amygdalina methanol leaf extract fractions on Ascaridia galli experimentally infected birds. Standard protocols for extraction, phytochemical screening, isolation infection parasite histological examination were followed. Result At 50 mg/ml albendazole (ALB) caused highest inhibition embryonation (97.3%) followed by crude (CME) (94.5%), ethyl acetate fraction (EAF) (81.3%) butanol (BF) (80.3%). The lowest faecal egg counts (FEC) FEC at 21 days post-treatment observed group treated (99.2%) CME 800 mg/kg (96.9%). Deparasitization 200 ALB (93.8%), while 200, 400 mg/kg, (77.5%, 87.5% 91.86%), BF (75.51%, 79.61% 85.73%) EAF (73.48%, 75.5% 81.63%), respectively. post-mortem, broiler chickens A. CME, had desquamation villi treatments, intestines intact. Conclusion V. found to possess activity against due eggs reduction count; further research required fully ascertain their mechanism action extract.